1st line drug options:

• nicotine replacement therapy
• Nicotine patch(Habitrol, Nicoderm)–expensive, skin sensitivity, nightmares, N&V, insomnia
• Nicotine gum(polacrilex, Nicorette)–temporary relief only
• Nicotine inhaler—cough, throat irritation, nightmares, N&V, insomnia

• bupropion 150mg QD x 3days, then 150mg BID x 7-12 weeks
• can cause seizure, liver dysfunction
• least expensive oral medication for smoking cessation, around CAN$100 per month

2nd line drugs:

• nortriptyline: has a lot of interactions with other drugs, herbs.
• Clonidine: causes low BP, dizziness, lightheadedness which may causing falling/faint, can`t be stopped abruptly since that will cause clonidine withdrawal syndrom—hypertension crisis, sometimes even missing a    dose can make you end up in ER.
• Varenicline: Nausea and vomiting is a very common SE.